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Pulmonary Function in Newborns After Repair of Congenital Diaphragmatic Hernia by Dr. Don K. Nakayama; Etsuro K. Motoyama; Rebecca L. Mutich; Anastassios C. Koumbourlis is a Medicine article available to read on EtoBox.

What is Pulmonary Function in Newborns After Repair of Congenital Diaphragmatic Hernia about?

Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia that limits survival, but the nature and extent of pulmonary dysfunction in neonates with CDH have not been studied. We performed pulmonary function tests (PFTs) in eight intubated infants who survived neonatal repair of CDH (wt, 3.33 +/- 0.15 kg; age, 20.1 +/- 2.7 d; mean +/- S.E.M.). PFTs obtained from six full-term infants (wt, 3.56 +/- 0.15 kg; age, 25.0 +/- 3.3 d) with no respiratory illness served as controls. The deflation flow-volume curve technique produced maximum expiratory flow-volume (MEFV) curves, giving reproducible measurements of forced vital capacity (FVC) and maximal expiratory flow at 25% of FVC (MEF25). Respiratory system compliance (Crs) and resistance (Rrs) were obtained with a modified passive mechanics technique. In seven of eight infants PFTs were repeated after nebulized bronchodilator (0.1% isoetharine). In neonates surviving CDH repair, as compared to those with normal lung function, FVC was significantly reduced (20.78 +/- 3.32 vs. 39.83 +/- 3.30 mL.kg-1, P less than 0.05). MEF25 was also markedly reduced (20.78 +/- 3.32 vs. 39.83 +/- 3.30 mL.kg-1.s-1, P less than 0.05), indi

Who reads Pulmonary Function in Newborns After Repair of Congenital Diaphragmatic Hernia?

Author

Dr. Don K. Nakayama; Etsuro K. Motoyama; Rebecca L. Mutich; Anastassios C. Koumbourlis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

1990

Language

EN

ISBN

9781950110100

Field

Medicine (Health Sciences)