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Design, Synthesis and Antimicrobial Properties of Non-hemolytic Cationic α-Cyclopeptoids by Daniela Comegna; Monica Benincasa; Renato Gennaro; Irene Izzo; Francesco De Riccardis is a scholarly article available to read on EtoBox.

What is Design, Synthesis and Antimicrobial Properties of Non-hemolytic Cationic α-Cyclopeptoids about?

The synthesis and screening of neutral and cationic, linear and cyclic peptoids (N-alkylglycine peptidomimetics) is described. Structure-activity relationship studies show that the in vitro activities of the tested peptoids depend on both cyclization and decoration with cationic groups. The most powerful N-lysine cyclopeptoid derivatives showed good antifungal activity against Candida albicans (ATCC90029 and L21) and Candida famata (SA550, Amph B-resistant) and low hemolytic activity. The effects of the cyclic peptoids on membrane permeabilization were evaluated by the propidium iodide exclusion assay.

Author

Daniela Comegna; Monica Benincasa; Renato Gennaro; Irene Izzo; Francesco De Riccardis

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2010

Language

EN