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Fibroblast Growth Factor-2 Deficiency Causes Defects in Adult Hippocampal Neurogenesis, Which Are Not Rescued by Exogenous Fibroblast Growth Factor-2 by Sandra Werner; Klaus Unsicker; Oliver von Bohlen und Halbach is a scholarly article available to read on EtoBox.

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## Abstract Neurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor‐2 (FGF‐2) in adult hippocampal neurogenesis has not been firmly established. We have analyzed neurogenesis in the DG using in vivo and in vitro approaches. FGF‐2^–/–^ mice revealed no alterations in the number of proliferating cells but a significant decrease in the numbers of newly generated neurons. Moreover, FGF‐2 added to hippocampal slice cultures from FGF‐2^–/–^ mice was unable to rescue the phenotype. Although an increase in death of neurogenic cells in the FGF‐2‐deficient DG could not be specifically demonstrated, there was a massive increase in global cell death in FGF‐2^–/–^ hippocampal slice cultures compared with slices from wild‐type mice. Cell death could not be prevented by addition of FGF‐2. Neutralization of endogenous FGF‐2 in hippocampal slices did not interfere with neurogenesis in a short‐term paradigm. Together, our data suggest that FGF‐2 is essentially required for maturation of new neurons in adult hippocampal neur

Author

Sandra Werner; Klaus Unsicker; Oliver von Bohlen und Halbach

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2011

Language

EN