About this Medicine article

Quality of treatment and surgical approach for rectal Gastrointestinal Stromal Tumour (GIST) in a large European cohort by Nikki S. IJzerman; Mahmoud Mohammadi; Dimitri Tzanis; Hans Gelderblom; Marco Fiore; Elena Fumagalli; Piotr Rutkowski; Elzbieta Bylina; Ioannis Zavrakidis; Neeltje Steeghs; Han J. Bonenkamp; Boudewijn van Etten; Dirk J. Grünhagen; Shahnawaz Rasheed; Paris Tekkis; Charles Honoré; Winan van Houdt; Jos van der Hage; Sylvie Bonvalot; Yvonne Schrage; Myles Smith is a Medicine article available to read on EtoBox.

## Background: Rectal gastrointestinal stromal tumours (gists) are rare tumours. variability in the management may influence outcome, but there is a lack of understanding regarding contemporary variance in care. a multicenter, international, retrospective cohort study was performed to elucidate characteristics and outcomes of rectal gist in european practice, with particular reference to surgical approach. ## Methods: All rectal gist patients diagnosed between 2009 and 2018 were identified from five european databases. recurrence free survival (rfs) and overall survival (os) were estimated using kaplan-meier method. possible confounders were identified using cox regression analyses. ## Results: From 210 patients, 155 patients had surgery. the three main types of surgery were local tumour resection (ltr, n = 46), low anterior resection (lar, n = 31) and abdomino-perineal resection (apr, n = 32). most patients received neoadjuvant (65%) and/or adjuvant imatinib therapy (66%). local recurrence rate after surgery was 15% and overall recurrence rate 28%. no significant differences were found in terms of rfs nor os between ltr, lar and apr. however, locally resected tumours were smaller,

Author

Nikki S. IJzerman; Mahmoud Mohammadi; Dimitri Tzanis; Hans Gelderblom; Marco Fiore; Elena Fumagalli; Piotr Rutkowski; Elzbieta Bylina; Ioannis Zavrakidis; Neeltje Steeghs; Han J. Bonenkamp; Boudewijn van Etten; Dirk J. Grünhagen; Shahnawaz Rasheed; Paris Tekkis; Charles Honoré; Winan van Houdt; Jos van der Hage; Sylvie Bonvalot; Yvonne Schrage; Myles Smith

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0748-7983)

Published

2020

Language

EN

Field

Medicine (Health Sciences)