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Within-subject sensitization of striatal dopamine release after a single injection of cocaine: An in vivo microdialysis study by Richard W. Keller Jr.; Isabelle M. Maisonneuve; Jeffrey N. Carlson; Stanley D. Glick is a Neuroscience article available to read on EtoBox.

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Repeated microdialysis measurements, conducted 1 week apart at the same tissue site, were used to investigate the changes in basal and cocaine-stimulated extracellular dopamine (DA) levels after a single prior exposure to either saline or cocaine. Dialysis probes were placed into rats previously implanted with guide cannulas and basal levels of dopamine (DA), and its metabolites (DOPAC and HVA) were estimated in 20-min fractions of the dialysate. Basal levels in the extracellular fluid (ECF), estimated from pre-implantation calibration of the probes, were 7.9 k 0.7 nM DA, 4.9 2 0.8 pM DOPAC, and 3.6 k 0.6 pM HVA. After a stable baseline was obtained saline (1 mVkg, i.p.) or cocaine (20 mgkg, i.p.1 was injected. Saline produced no significant changes in any of the neurochemical markers. A cocaine injection produced a sixfold increase in DA, while DOPAC and HVA were unchanged. One week later the same procedure was repeated except this time both groups received cocaine. In rats that had received cocaine 1 week earlier, basal DA levels in the ECF were doubled, whereas they were unchanged in rats that received saline a week earlier. Furthermore, the dopamine release in response to acute

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Author

Richard W. Keller Jr.; Isabelle M. Maisonneuve; Jeffrey N. Carlson; Stanley D. Glick

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)