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Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases by Michel Legraverend; Odile Ludwig; Emile Bisagni; Sophie Leclerc; Laurent Meijer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases about?

The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at C2. They inhibit CDK's with IC50's in the 200 nM range.

Who reads Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases?

Author

Michel Legraverend; Odile Ludwig; Emile Bisagni; Sophie Leclerc; Laurent Meijer

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)