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Is whole‐brain irradiation necessary for primary central nervous system lymphoma?: Patterns of recurrence after partial‐brain irradiation by Yuta Shibamoto; Naofumi Hayabuchi; Jun‐ichi Hiratsuka; Sunao Tokumaru; Hiroki Shirato; Mitsuharu Sougawa; Natsuo Oya; Yuji Uematsu; Masahiro Hiraoka is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND Neurotoxicity after whole‐brain irradiation remains a major problem in the treatment of primary central nervous system lymphoma (PCNSL). To clarify whether whole‐brain radiation is necessary for PCNSL, the authors retrospectively analyzed the outcome of patients treated with partial‐brain irradiation. ## METHODS A nationwide survey was performed regarding the treatment of PCNSL. Among 62 institutions surveyed, 7 were identified in which whole‐brain irradiation was not necessarily employed. Questionnaires were sent to these institutions and 43 patients who had been treated using partial‐brain fields since 1985 were collected. Thirty‐two patients had solitary lesions and 11 had multiple lesions. Patterns of recurrence could be identified in 38 patients. ## RESULTS The cumulative in‐field and out‐field recurrence rates at 5 years were 57% and 49%, respectively. Of 14 out‐field recurrences, 2 occurred at the safety margin of the previous radiation field. The out‐field recurrence rate was 45% in patients with a single lesion and 67% in those with multiple tumors (__P__ = 0.79). The out‐field recurrence rate was 22% for patients treated with safety margins of ≥
Who reads Is whole‐brain irradiation necessary for primary central nervous system lymphoma?: Patterns of recurrence after partial‐brain irradiation?
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- Author
- Yuta Shibamoto; Naofumi Hayabuchi; Jun‐ichi Hiratsuka; Sunao Tokumaru; Hiroki Shirato; Mitsuharu Sougawa; Natsuo Oya; Yuji Uematsu; Masahiro Hiraoka
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)