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1. Diuretics work at different segments of the nephron to promote excretion of water and ions like sodium, potassium, and chloride. They are classified based on their site and mechanism of action. 2. Loop diuretics like furosemide work in the thick ascending limb of the loop of Henle by inhibiting the Na-K-2Cl transporter. They are highly effective at promoting natriuresis but can cause hypokalemia. 3. Thiazide diuretics like hydrochlorothiazide work in the distal convoluted tubule by inhibiting the sodi

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