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MPTP‐induced parkinsonism: Acceleration of biochemical and behavioral recovery by GM~1~ ganglioside treatment by Dr. J. S. Schneider is a Neuroscience article available to read on EtoBox.

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## Abstract The effects of GM~1~ ganglioside administration on functional recovery and recovery of caudate nucleus dopamine levels have been assessed in cats made parkinsonian by administration of the dopaminergic neurotoxin l‐methyl‐4‐phenyl‐ 1,2,3, 6‐tetrahydropyridine (MPTP). Cats made severely parkinsonian by MPTP administration began to show spontaneous functional recovery by the third week after MPTP, as had been observed in previous studies with this model. In contrast, cats with similar initial impairment but which received 3 weeks of GM~1~ ganglioside treatment (30 mg/kg, i.p. daily) showed an accelerated behavioral recovery, showing significant functional improvement after the first week of GM~1~ treatment and almost normal function by the end of the third week of treatment. The GM~1~‐treated cats had caudate nucleus dopamine, 3,4‐dihydroxyphenylacetic acid (DOPAC), and HVA levels significantly increased above levels measured in saline‐treated MPTP control cats. A second group of cats received MPTP only until the first signs of parkinsonism were observed and thus overall had a less severe initial syndrome than the cats described previously. Again, while all cats showed fu

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Author

Dr. J. S. Schneider

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)