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This study investigates the spatial organization of hepatic endoplasmic reticulum (ER) and mitochondria during fasting and obesity using high-resolution electron microscopy. It reveals that fasting induces significant remodeling of ER architecture and enhances interactions with mitochondria, particularly in periportal and mid-lobular hepatocytes, while these adaptations are impaired in obesity. The findings highlight the importance of regulated subcellular architecture for metabolic flexibility in hepatocyt

Author

Regis Correia

Language

EN