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Can I read Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy on EtoBox?
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy by Yuan, Xiaoyan; Chen, Guo; Guo, Dongfeng; Xu, Lei; Gu, Yongfeng is a Immunology and Microbiology article available to read on EtoBox.
What is Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy about?
Sepsis is a life-threatening condition. Polydatin (PD), a small natural compound from Polygonum cuspidatum, possesses antioxidant and anti-inflammatory properties. However, the protective mechanism of PD on sepsis-induced acute myocardial damage is still unclear. The aim of this study was to investigate the effect and mechanism of action of PD on lipopolysaccharide (LPS)-induced H9c2 cells and in a rat model of sepsis, and explored the role of PD-upregulated sirtuin (SIRT)6. LPS-induced H9c2 cells were used to simulate sepsis. Cecal ligation and puncture (CLP)-induced sepsis in rats were used to verify the protective effect of PD. ELISA, western blotting, immunofluorescence, immunohistochemistry, and flow cytometry were used to study the protective mechanism of PD against septic myocardial injury. PD pretreatment suppressed LPS-induced H9c2 cell apoptosis by promotion of SIRT6-mediated autophagy. Downregulation of SIRT6 or inhibition of autophagy reversed the protective effect of PD on LPS-induced apoptosis. PD pretreatment also suppressed LPS-induced inflammatory factor expression. CLP-induced sepsis in rats showed that PD pretreatment decreased CLP-induced myocardial apoptosis an
Who reads Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Yuan, Xiaoyan; Chen, Guo; Guo, Dongfeng; Xu, Lei; Gu, Yongfeng
- Publisher
- Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0360-3997)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)