Can I read Feasibility of Quantitative and Volumetric Enhancement Measurement to Assess Tumor Response in Patients with Breast Cancer After Early Neoadjuvant Chemotherapy on EtoBox?

Feasibility of Quantitative and Volumetric Enhancement Measurement to Assess Tumor Response in Patients with Breast Cancer After Early Neoadjuvant Chemotherapy by Jie Ding; Hongyan Xiao; Weiwei Deng; Fengjiao Liu; Rongrong Zhu; Ruoshui Ha is a scholarly article available to read on EtoBox.

What is Feasibility of Quantitative and Volumetric Enhancement Measurement to Assess Tumor Response in Patients with Breast Cancer After Early Neoadjuvant Chemotherapy about?

## Objective To evaluate the feasibility of quantitative enhancing lesion volume (ELV) for evaluating the responsiveness of breast cancer patients to early neoadjuvant chemotherapy (NAC) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). ## Methods Seventy-five women with breast cancer underwent DCE-MRI before and after NAC. Lesions were assessed by ELV, response evaluation criteria in solid tumors 1.1 (RECIST 1.1), and total lesion volume (TLV). The diagnostic and pathological predictive performances of the methods were compared and color maps were compared with pathological results. ## Results ELV identified 29%, 67%, and 4% of cases with partial response, stable disease, and progressive disease, respectively. There was no significant difference in evaluation performances among the methods. The sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of ELV for predicting pathologic response were 72%, 92%, 81.8%, 86.8%, and 85.3%, respectively, with the highest sensitivity, NPV, and accuracy of the three methods. The area under the receiver operating characteristic curve was also highest for ELV. Pre- and post-NAC color

Author

Jie Ding; Hongyan Xiao; Weiwei Deng; Fengjiao Liu; Rongrong Zhu; Ruoshui Ha

Publisher

SAGE Publications

Published

2021

Language

EN