Can I read Micro- and Nano-plastics Activation of Oxidative and Inflammatory Adverse Outcome Pathways on EtoBox?

Micro- and Nano-plastics Activation of Oxidative and Inflammatory Adverse Outcome Pathways by Moyan Hu; Dušan Palić is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Micro- and Nano-plastics Activation of Oxidative and Inflammatory Adverse Outcome Pathways about?

Microplastics (MPs) and nanoplastics (NPs) have attracted considerable attention in the recent years as potential threats to the ecosystem and public health. This review summarizes current knowledge of pathological events triggered by micro- and nano-plastics (MP/NPs) with focus on oxidative damages at different levels of biological complexity (molecular, cellular, tissue, organ, individual and population). Based on published information, we matched the apical toxicity endpoints induced by MP/NPs with key event (KE) or adverse outcomes (AO) and categorized them according to the Adverse Outcome Pathway (AOP) online knowledgebase. We used existing AOPs and applied them to highlight formal mechanistic links between identified KEs and AOs in two possible scenarios: first from ecological, and second from public health perspective. Ecological perspective AOP based literature analysis revealed that MP/NPs share formation of reactive oxygen species as their molecular initiating event, leading to adverse outcomes such as growth inhibition and behavior alteration through oxidative stress cascades and inflammatory responses. Application of AOP on literature data related to public health persp

Who reads Micro- and Nano-plastics Activation of Oxidative and Inflammatory Adverse Outcome Pathways?

Author

Moyan Hu; Dušan Palić

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)