Can I read A convenient solid phase synthesis of S-palmitoyl transmembrane peptides on EtoBox?
A convenient solid phase synthesis of S-palmitoyl transmembrane peptides by Dirk T.S. Rijkers; John A.W. Kruijtzer; J. Antoinette Killian; Rob M.J. Liskamp is a Chemistry article available to read on EtoBox.
What is A convenient solid phase synthesis of S-palmitoyl transmembrane peptides about?
S-Palmitoylated peptides are important tools as models for integral membrane proteins to study peptide-lipid interactions. Herein, we report a convenient solid phase synthesis of S-palmitoyl transmembrane peptides. The highly acid labile S-(4-methoxytrityl) group is preferred over the S-(tert-butylsulfanyl) group for protection of the cysteine side chain since the latter gives rise to quantitative desulfurization during on-resin deprotection. The resulting free thiol function is modified with palmitic acid via a carbodiimide-mediated coupling and the title compounds are obtained in good yields and purity.
Who reads A convenient solid phase synthesis of S-palmitoyl transmembrane peptides?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Dirk T.S. Rijkers; John A.W. Kruijtzer; J. Antoinette Killian; Rob M.J. Liskamp
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)