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Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation by Schwob, James E.; Youngentob, Steven L.; Ring, George; Iwema, Carrie L.; Mezza, Renee C. is a Neuroscience article available to read on EtoBox.
What is Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation about?
We used the inhalation of methyl bromide gas to produce a near-complete destruction of the rat olfactory epithelium and analyzed the reinnervation of the bulb during reconstitution of the epithelium. The degeneration of olfactory axons elicits a transient up-regulation of glial cell proliferation and glial fibrillary acidic protein expression in the olfactory nerve and olfactory nerve layer of the bulb. Anterograde transport after intranasal infusion of wheat germ agglutinin conjugated horseradish peroxidase demonstrates that the first nascent axons reach the bulb within the first week after lesion. Subsequently, a massive wave of fibers arrives at the bulb between 1 and 2 weeks postlesion, and enters the glomeruli between 2 and 3 weeks postlesion. However, the olfactory projection does not stabilize until 8 weeks after lesion judging from the return in growth associated protein-43 expression to control levels. The extent of reinnervation after lesion is correlated with the completeness with which the epithelium reconstitutes itself. In rats that are lesioned while fed ad libitum, there is near-complete reconstitution of the neuronal population, and the projection onto the bulb fil
Who reads Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Schwob, James E.; Youngentob, Steven L.; Ring, George; Iwema, Carrie L.; Mezza, Renee C.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 1999
- Language
- EN
- Field
- Neuroscience (Life Sciences)