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What is Cholangiocyte Niche in Biliary Atresia about?
This study identifies a pathogenic cholangiocyte niche in biliary atresia (BA) and highlights TNFRSF12A as a potential therapeutic target. Through single-cell RNA sequencing and spatial transcriptomics, researchers found a cholangiocyte-enriched niche associated with liver fibrosis and poor patient survival. Targeting TNFRSF12A may suppress liver injury and inflammation, offering a new avenue for BA treatment.
- Author
- 3417534739
- Language
- EN