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Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases by Luzar, Boštjan; Ieremia, Eleni; Antonescu, Cristina R.; Zhang, Lei; Calonje, Eduardo is a Medicine article available to read on EtoBox.

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Pure intravascular growth of epithelioid hemangioma (EH) is exceptional. Herein, we report a series of 21 intravascular EHs, representing a potential serious diagnostic pitfall by mimicking malignant vascular neoplsms with epithelioid morphology. The tumors developed in 12 males and 4 females, aged from 11 to 71 years (mean age 40.2 years) with a predilection for the extremities (13 of 21, 61.9%), followed by the head and neck (8 of 21, 38.1%). Lesions ranged in size from 2 to 30 mm (mean size 13 mm). The most common presenting feature was a slowly growing nodule. Most neoplasms were solitary (13 of 16 patients, 81.2%) but three patients developed more than one intravascular EH (3 of 16, 18.8%). Treatment consisted of complete surgical excision and was generally curative. Follow-up was available for 13 lesions that had developed in ten patients (range 4-72 months, mean 27.3 months). No recurrences or development of additional tumors were observed. All 21 lesions developed in subcutaneous veins. Two morphological patterns of intravascular epithelioid endothelial cell proliferation were observed: (1) a lobular capillary hemangioma-like proliferation with variable formation of open va

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Author

Luzar, Boštjan; Ieremia, Eleni; Antonescu, Cristina R.; Zhang, Lei; Calonje, Eduardo

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)