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Assessment of health-related quality of life as an outcome measure in granulomatosis with polyangiitis (Wegener's) by Gunnar Tomasson; Maarten Boers; Michael Walsh; Michael LaValley; David Cuthbertson; Simon Carette; John C. Davis; Gary S. Hoffman; Nader A. Khalidi; Carol A. Langford; Carol A. Mcalear; W. Joseph McCune; Paul A. Monach; Philip Seo; Ulrich Specks; Robert Spiera; E. William St. Clair; John H. Stone; Steven R. Ytterberg; Peter A. Merkel is a Medicine article available to read on EtoBox.

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## Abstract ## Objective To assess a generic measure of health‐related quality of life (HRQOL) as an outcome measure in granulomatosis with polyangiitis (Wegener's) (GPA). ## Methods Subjects were participants in the Wegener's Granulomatosis Etanercept Trial (WGET) or the Vasculitis Clinical Research Consortium Longitudinal Study (VCRC‐LS). HRQOL was assessed with the Short Form 36 (SF‐36) health survey that includes physical and mental component summary scores (PCS and MCS, respectively). Disease activity was assessed with the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). ## Results The data from 180 subjects in the WGET (median followup 2.3 years, mean number of visits 10) and 237 subjects in the VCRC‐LS (median followup 2.0 years, mean number of visits 8) were analyzed. A 1 unit increase in the BVAS/WG corresponded to a 1.15 unit (95% confidence interval [95% CI] 1.02, 1.29) decrease for the PCS and a 0.93 (95% CI 0.78, 1.07) decrease for the MCS in the WGET, and to a 1.16 unit decrease for the PCS (95% CI 0.94, 1.39) and a 0.79 unit decrease for the MCS (95% CI 0.51, 1.39) in the VCRC‐LS. In both arms of the WGET study, SF‐36 measures improved rap

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Author

Gunnar Tomasson; Maarten Boers; Michael Walsh; Michael LaValley; David Cuthbertson; Simon Carette; John C. Davis; Gary S. Hoffman; Nader A. Khalidi; Carol A. Langford; Carol A. Mcalear; W. Joseph McCune; Paul A. Monach; Philip Seo; Ulrich Specks; Robert Spiera; E. William St. Clair; John H. Stone; Steven R. Ytterberg; Peter A. Merkel

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 2151-464X)

Published

2012

Language

EN

Field

Medicine (Health Sciences)