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Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics by Donald A. MacKenzie; Marianne Defernez; Warwick B. Dunn; Marie Brown; Linda J. Fuller; Santiago R. M. Seco de Herrera; Andreas Günther; Steve A. James; John Eagles; Mark Philo; Royston Goodacre; Ian N. Roberts is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics about?
## Abstract Ten medically important __Saccharomyces__ strains, comprising six clinical isolates of __Saccharomyces cerevisiae__ and four probiotic strains of __Saccharomyces boulardii__, were characterized at the genetic and metabolic level and compared with non‐medical, commercial yeast strains used in baking and wine‐making. Strains were compared by genetic fingerprinting using amplified fragment length polymorphism (AFLP) analysis, by ribosomal DNA __ITS1__ sequencing and by metabolic footprinting using both direct injection mass spectrometry (DIMS) and gas chromatography–time of flight–mass spectrometry (GC–ToF–MS). Overall, the clinical isolates fell into different groupings when compared with the non‐medical strains, with good but not perfect correlation amongst strains at both the genetic and metabolic levels. Probiotic strains of __S. boulardii__ that are used therapeutically to treat human gastro‐intestinal tract disorders showed tight clustering both genetically and metabolically. Metabolomics was found to be of value both as a taxonomic tool and as a means to investigate anomalous links between genotype and phenotype. Key discriminatory metabolites were identified when c
Who reads Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Donald A. MacKenzie; Marianne Defernez; Warwick B. Dunn; Marie Brown; Linda J. Fuller; Santiago R. M. Seco de Herrera; Andreas Günther; Steve A. James; John Eagles; Mark Philo; Royston Goodacre; Ian N. Roberts
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)