About this Medicine article

Intensified Adjuvant Combined Modality Therapy for Resected Periampullary Adenocarcinoma: Acceptable Toxicity and Suggestion of Improved 1-Year Disease-free Survival by Anuradha Chakravarthy; Ross A Abrams; Charles J Yeo; Larry T Korman; Ross C Donehower; Ralph H Hruban; Marianna L Zahurek; Louise B Grochow; Seamus O’Reilly; Herbert Hurwitz; Elizabeth M Jaffee; Keith D Lillemoe; John L Cameron is a Medicine article available to read on EtoBox.

## Purpose: (1) to determine the toxicity of an intensified postoperative adjuvant regimen for periampullary adenocarcinoma (pancreatic and nonpancreatic) utilizing concurrent 5-fluorouracil (5-fu), leucovorin (lv), dipyridamole (dpm), and mitomycin-c (mmc) combined with split-course locoregional external beam radiotherapy (ebrt) to 50 gy. this was followed by 4 cycles of the same chemotherapy as adjuvant therapy. (2) to determine preliminary estimates of the overall and disease-free survival associated with the use of this regimen. (3) to compare the toxicities and early survival results of patients treated with the current regimen to those of patients who completed our prior trial of concurrent chemoradiation infusion with 5-fu/lv chemotherapy and regional nodal and prophylactic hepatic irradiation. ## Methods: Postpancreaticoduodenectomy, patients received every 4 weeks bolus administration of 5-fu, (400 mg/m(2)), and lv, (20 mg/m(2), days l-3), dpm (75 mg p.o., 4 times per day, days 0-3, and every 8 weeks), mmc, (10 mg/m(2); maximum of 20 mg, day l during ebrt). this was followed by 4 months of the same chemotherapy, beginning 1 month following the completion of ebrt. ebrt cons

Author

Anuradha Chakravarthy; Ross A Abrams; Charles J Yeo; Larry T Korman; Ross C Donehower; Ralph H Hruban; Marianna L Zahurek; Louise B Grochow; Seamus O’Reilly; Herbert Hurwitz; Elizabeth M Jaffee; Keith D Lillemoe; John L Cameron

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2000

Language

EN

Field

Medicine (Health Sciences)