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The Past, Present, and Future Physiology and Pharmacology of Glucagon by Megan E. Capozzi; David A. D’Alessio; Jonathan E. Campbell is a Medicine article available to read on EtoBox.

What is The Past, Present, and Future Physiology and Pharmacology of Glucagon about?

The evolution of glucagon has seen the transition from an impurity in the preparation of insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 diabetes, glucagon receptor antagonists have been explored to reduce glycemia thought to be induced by hyperglucagonemia. However, the catabolic actions of glucagon are currently being leveraged to target the rise in obesity that paralleled that of diabetes, bringing the pharmacology of glucagon full circle. During this evolution, the physiological importance of glucagon advanced beyond the control of hepatic glucose production, incorporating critical roles for glucagon to regulate both lipid and amino acid metabolism. Thus, it is unsurprising that the study of glucagon has left several paradoxes that make it difficult to distill this hormone down to a simplified action. Here, we describe the history of glucagon from the past to the present and suggest some direction to the future of this field.

Who reads The Past, Present, and Future Physiology and Pharmacology of Glucagon?

Author

Megan E. Capozzi; David A. D’Alessio; Jonathan E. Campbell

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Life Sciences)