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Can I read Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2 on EtoBox?
Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2 by Joel O. Wertheim; Reilly Hostager; Diane Ryu; Kevin Merkel; Samuel Angedakin; Mimi Arandjelovic; Emmanuel Ayuk Ayimisin; Fred Babweteera; Mattia Bessone; Kathryn J. Brun-Jeffery; Paula Dieguez; Winnie Eckardt; Barbara Fruth; Ilka Herbinger; Sorrel Jones; Hjalmar Kuehl; Kevin E. Langergraber; Kevin Lee; Nadege F. Madinda; Sonja Metzger; Lucy Jayne Ormsby; Martha M. Robbins; Volker Sommer; Tara Stoinski; Erin G. Wessling; Roman M. Wittig; Yisa Ginath Yuh; Fabian H. Leendertz; Sébastien Calvignac-Spencer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2 about?
## Abstract Viruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and cross-species transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experienced multiple cross-species transmission events over the past 3 My, the most recent of which occurred between humans and bonobos around 1 Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens.
Who reads Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Joel O. Wertheim; Reilly Hostager; Diane Ryu; Kevin Merkel; Samuel Angedakin; Mimi Arandjelovic; Emmanuel Ayuk Ayimisin; Fred Babweteera; Mattia Bessone; Kathryn J. Brun-Jeffery; Paula Dieguez; Winnie Eckardt; Barbara Fruth; Ilka Herbinger; Sorrel Jones; Hjalmar Kuehl; Kevin E. Langergraber; Kevin Lee; Nadege F. Madinda; Sonja Metzger; Lucy Jayne Ormsby; Martha M. Robbins; Volker Sommer; Tara Stoinski; Erin G. Wessling; Roman M. Wittig; Yisa Ginath Yuh; Fabian H. Leendertz; Sébastien Calvignac-Spencer
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)