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This document presents a bio-inspired total synthesis of tetrahydrofuran lignans, specifically the first total synthesis of tanegool and a concise synthesis of pinoresinol. The authors propose a novel approach that utilizes oxidative ring opening of diarylcyclobutane to address challenges in controlling selectivity during lignan biosynthesis. The effectiveness of this method is demonstrated through successful synthesis steps starting from ferulic acid, highlighting its potential for further applications in

Author

Ira Novita Sari

Language

EN