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Polydopamine-coated Polycaprolactone/carbon Nanotube Fibrous Scaffolds Loaded with Brain-derived Neurotrophic Factor for Peripheral Nerve Regeneration by Wei Pi; Yanling Zhang; Longfei Li; Ci Li; Meng Zhang; Wei Zhang; Qing Cai; Peixun Zhang is a Engineering article available to read on EtoBox.
What is Polydopamine-coated Polycaprolactone/carbon Nanotube Fibrous Scaffolds Loaded with Brain-derived Neurotrophic Factor for Peripheral Nerve Regeneration about?
## Abstract Carbon nanotubes (CNTs) have attracted increasing attention in the field of peripheral nerve tissue engineering due to their unique structural and physical characteristics. In this study, a novel type of aligned conductive scaffolds composed of polycaprolactone (PCL) and CNTs were fabricated via electrospinning. Utilizing mussel-inspired polydopamine (PDA) surface modification, brain-derived neurotrophic factor (BDNF) was loaded onto PCL/CNT fibrous scaffolds to obtain PCL/CNT-PDA-BDNF fibrous scaffolds capable of the sustained release of BDNF over 28 d. Schwann cells were cultured on these scaffolds, and the effect of the scaffolds on peripheral nerve regeneration in vitro was assessed by studying cell proliferation, morphology and the expressions of myelination-related genes S100, P0 and myelin basic protein. Furthermore, the effect of these scaffolds on peripheral nerve regeneration in vivo was investigated using a 10 mm rat sciatic nerve defect model. Both the in vitro and in vivo results indicate that PCL/CNT-PDA-BDNF fibrous scaffolds effectively promote sciatic nerve regeneration and functional recovery. Therefore, PCL/CNT-PDA-BDNF fibrous scaffolds have great po
Who reads Polydopamine-coated Polycaprolactone/carbon Nanotube Fibrous Scaffolds Loaded with Brain-derived Neurotrophic Factor for Peripheral Nerve Regeneration?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Wei Pi; Yanling Zhang; Longfei Li; Ci Li; Meng Zhang; Wei Zhang; Qing Cai; Peixun Zhang
- Publisher
- IOP Publishing
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)