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Tumour necrosis factor-α but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation by Kazuhiro Kikuchi; Yoshiki Yanagawa; Toshimasa Aranami; Chikako Iwabuchi; Kazuya Iwabuchi; Kazunori Onoé is a Immunology and Microbiology article available to read on EtoBox.
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## Summary Using murine spleen‐derived dendritic cells (DC) and DO11.10 T cells specific for ovalbumin (OVA), the influences of maturational condition and antigen dose on the capability of DC to induce helper T‐cell (Th) differentiation were analysed. Immature DC (iDC) with high‐ or low‐dose OVA~323–339~ predominantly induced Th1 or Th2 responses in DO11.10 T cells, respectively. DC matured by tumour necrosis factor‐α (TNF/DC) induced a significantly higher Th2 response in the presence of low‐dose OVA~323–339~ than iDC and DC matured by lipopolysaccharide (LPS) (LPS/DC). In the presence of high‐dose OVA~323–339~, LPS/DC induced significantly lower levels of Th1 response than iDC. Under these conditions no difference in the Th1 response was noted between TNF/DC and iDC. The enhanced capability of TNF/DC with a low‐dose antigen for Th2 polarization and the decreased preference of LPS/DC with a high‐dose antigen to Th1 polarization were not related to the amount of IL‐12 produced in these cultures. These results demonstrate for the first time that TNF/DC with a low‐dose antigen are potent inducers of Th2 differentiation.
Who reads Tumour necrosis factor-α but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Kazuhiro Kikuchi; Yoshiki Yanagawa; Toshimasa Aranami; Chikako Iwabuchi; Kazuya Iwabuchi; Kazunori Onoé
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)
- Published
- 2003
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)