Opening book details…
Can I read Site-specific Time Heterogeneity of the Substitution Process and Its Impact on Phylogenetic Inference on EtoBox?
Site-specific Time Heterogeneity of the Substitution Process and Its Impact on Phylogenetic Inference by Béatrice Roure; Hervé Philippe is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Site-specific Time Heterogeneity of the Substitution Process and Its Impact on Phylogenetic Inference about?
## Background Model violations constitute the major limitation in inferring accurate phylogenies. Characterizing properties of the data that are not being correctly handled by current models is therefore of prime importance. One of the properties of protein evolution is the variation of the relative rate of substitutions across sites and over time, the latter is the phenomenon called heterotachy. Its effect on phylogenetic inference has recently obtained considerable attention, which led to the development of new models of sequence evolution. However, thus far focus has been on the quantitative heterogeneity of the evolutionary process, thereby overlooking more qualitative variations. ## Results We studied the importance of variation of the site-specific amino-acid substitution process over time and its possible impact on phylogenetic inference. We used the CAT model to define an infinite mixture of substitution processes characterized by equilibrium frequencies over the twenty amino acids, a useful proxy for qualitatively estimating the evolutionary process. Using two large datasets, we show that qualitative changes in site-specific substitution properties over time occurred signi
Who reads Site-specific Time Heterogeneity of the Substitution Process and Its Impact on Phylogenetic Inference?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Béatrice Roure; Hervé Philippe
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2148)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)