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1. The 2013 ACC/AHA guidelines emphasize statins as first-line therapy for lowering cholesterol and cardiovascular risk in three high-risk groups: those with clinical atherosclerotic cardiovascular disease, LDL over 190 mg/dl, and diabetics aged 40-75 with LDL of 70-189 mg/dl. 2. The guidelines recommend high-intensity statin therapy for those with a 10-year risk of atherosclerotic cardiovascular disease over 7.5%, and moderate-intensity statin therapy for those under 7.5%, as calculated using the Pooled

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erty543 er

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