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IgG antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients with morphea in Colombia by Ricardo Palacios; Antonio Torres; Rodolfo Trujillo is a Medicine article available to read on EtoBox.

What is IgG antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients with morphea in Colombia about?

## Abstract **Background** Morphea and lichen sclerosus et atrophicus (LSA) are sclerotic skin lesions of unknown etiology involving connective tissue. The hypothesis of a borrelial origin of morphea and LSA is currently controversial. **Methods** Immunoglobulin G (IgG) immunoblot serologies against __Borrelia burgdorferi__ in patients with morphea and LSA were analyzed and compared with those from healthy donors and patients with syphilis to determine the association with a probable borrelial agent in Colombia. **Results** No significant differences in the number of reactive antigenic bands were found between morphea/LSA patients and syphilis patients or healthy donors. The presence of at least one of the following bands, p28, p39, or p45, was the criterion most able to distinguish morphea/LSA, yielding a specificity of 95% and a sensitivity of 28.6%. Using this criterion as evidence of putative exposure to a causative borrelial agent, sclerotic skin lesions had an odds ratio of 7.60 (95% confidence interval, 1.47–39.23). **Conclusions** These results could be explained by cross‐reactivity; however, the partial shared reactivity of sera from patients with syphilis and morphea/LSA

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Author

Ricardo Palacios; Antonio Torres; Rodolfo Trujillo

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0011-9059)

Published

2003

Language

EN

Field

Medicine (Health Sciences)