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Can I read Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases on EtoBox?
Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases by Wim Ceelen; Robert G. Ramsay; Vignesh Narasimhan; Alexander G. Heriot; Olivier De Wever is a Medicine article available to read on EtoBox.
What is Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases about?
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (IP) delivery of chemotherapy, is limited. Increasingly, therefore, efforts are being developed to unravel the PM cascade and at understanding the PM-associated tumor microenvironment (TME) and peritoneal ecosystem as potential therapeutic targets. Here, we review recent insights in the structure and components of the TME in colorectal PM, and discuss how these may translate into novel therapeutic approaches aimed at re-engineering the metastasis-promoting activity of the stroma.
Who reads Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wim Ceelen; Robert G. Ramsay; Vignesh Narasimhan; Alexander G. Heriot; Olivier De Wever
- Publisher
- Elsevier ; Cell Press; Elsevier BV (ISSN 2405-8033)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)