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Non‐steroidal Anti‐inflammatory Drugs with Different Cyclooxygenase Inhibitory Profiles That Prevent Aberrant Crypt Foci Formation but Vary in Acute Gastrotoxicity in a Rat Model ^1^ by Wendy A Brown; Stewart A Skinner; Caterina Malcontenti-Wilson; Aileen Misajon; Tanya Dejong; Daphne Vogiagis; Paul E O’Brien is a scholarly article available to read on EtoBox.

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## Background: Standard non-steroidal anti-inflammatory drugs (nsaids) reduce the risk of colorectal cancer; however, their use as preventive agents is limited by their inherent toxicity. drugs that selectively inhibit cyclooxygenase-2 (cox-2) may be useful in this setting as they are supposedly less toxic. no study has directly compared the ability of standard nsaids and selective cox-2 inhibitors to inhibit colorectal cancer at clinically relevant doses. ## Methods: Aberrant crypt foci (acf) were induced in sprague-dawley rats by using 1,2-dimethylhydrazine (dmh). test agents or vehicle were then administered for 3 weeks, twice daily through orogastric gavage. at the end of this period, the number and multiplicity of acf were determined. the agents tested at equivalent anti-inflammatory doses were: sulindac and indomethacin (standard nsaids), meloxicam (selective cox-2 inhibitor), celecoxib (specific cox-2 inhibitor) and sulindac sulfone (no known cox activity). acute gastrotoxicity of nsaid in rats was compared by using quantitative histology. ## Results: All test agents reduced the number of acf. there was a 42% reduction with indomethacin, 46% with sulindac, 46% with meloxicam

Author

Wendy A Brown; Stewart A Skinner; Caterina Malcontenti-Wilson; Aileen Misajon; Tanya Dejong; Daphne Vogiagis; Paul E O’Brien

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)

Published

2001

Language

EN