Can I read SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer on EtoBox?

SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer by Steven P. Zielske; Wei Chen; Kristina G. Ibrahim; Frank C. Cackowski is a Medicine article available to read on EtoBox.

What is SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer about?

## Abstract ## Background A majority of prostate cancer cells are in a non-proliferating, G~0~ (quiescent) phase of the cell cycle and may lie dormant for years before activation into a proliferative, rapidly progressing, disease phase. Many mechanisms which influence proliferation and quiescence choices remain to be elucidated, including the role of non-coding RNAs. In this study, we investigated the role of a long non-coding RNA (lncRNA), SNHG1, on cell proliferation, quiescence, and sensitivity to docetaxel as a potential factor important in prostate cancer biology. ## Methods Publically available, anonymous, clinical data was obtained from cBioPortal for analysis. RNAi and prostate cancer cell lines were utilized to investigate SNHG1 in vitro. We measured G~0~ cells, DNA synthesis, and cell cycle distribution by flow cytometry. Western blotting was used to assess G~2~ arrest and apoptosis. These parameters were also investigated following docetaxel treatment. ## Results We discovered that in prostate cancer patients from The Cancer Genome Atlas (TCGA) data set, high SNHG1 expression in localized tumors correlated with reduced progression-free survival, and in a data set of both

Who reads SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer?

Author

Steven P. Zielske; Wei Chen; Kristina G. Ibrahim; Frank C. Cackowski

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)