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Challenging the Fundamental Conjectures in Nanoparticle Drug Delivery for Chemotherapy Treatment of Solid Cancers by Juanjuan Yang; Xiaojin Wang; Bingshun Wang; Kinam Park; Karen Wooley; Shiyi Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Challenging the Fundamental Conjectures in Nanoparticle Drug Delivery for Chemotherapy Treatment of Solid Cancers about?

Nanomedicines for cancer treatment have been studied extensively over the last few decades. Yet, only five anticancer nanomedicines have received approvals from the United States Food and Drug Administration (FDA) for treating solid tumors. This drastic mismatch between effort and return calls into question the basic understanding of this field. Various viewpoints on nanomedicines have been presented regarding their potentials and inefficiencies. However, the underlying logics of nanomedicine research and its inadequate translation to the successful use in the clinic have not been thoroughly examined. Tumor-targeted drug delivery was used to understand the shortfalls of the nanomedicine field in general. The concept of tumor-targeted drug delivery by nanomedicine has been based on two conjectures: (i) increased drug delivery to tumors provides better efficacy, and (ii) decreased drug delivery to healthy organs results in fewer side effects. The clinical evidence gathered from the literature indicates that nanomedicines bearing classic chemotherapeutic drugs, such as Dox, cis-Pt, CPT and PTX, have already reached the maximum drug delivery limit to solid tumors in humans. Still, the

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Author

Juanjuan Yang; Xiaojin Wang; Bingshun Wang; Kinam Park; Karen Wooley; Shiyi Zhang

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)