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Maternal High-fat Diet Reversal Improves Placental Hemodynamics in a Nonhuman Primate Model of Diet-induced Obesity by Salati, Jennifer A.; Roberts, Victoria H. J.; Schabel, Matthias C.; Lo, Jamie O.; Kroenke, Christopher D.; Lewandowski, Katherine S.; Lindner, Jonathan R.; Grove, Kevin L.; Frias, Antonio E. is a Medicine article available to read on EtoBox.

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## Background: In a japanese macaque model of diet-induced obesity, we have previously demonstrated that consumption of a high-fat, "western-style" diet (wsd) is associated with placental dysfunction and adverse pregnancy outcomes, independent of an obese maternal phenotype. specifically, we have reported decreased uterine placental blood flow and increased inflammation with maternal wsd consumption. we also previously investigated the use of a promising therapeutic intervention that mitigated the adverse placental effects of a wsd but had unexpected detrimental effects on fetal pancreatic development. thus, the objective of the current study was to determine whether simple preconception diet reversal (rev) would improve placental function. ## Methods: Female japanese macaques were divided into three groups: rev animals (n = 5) were switched from a chronic wsd (36% fat) to a low fat, con diet (14% fat) prior to conception and throughout pregnancy. the con (n = 6) and wsd (n = 6) cohorts were maintained on their respective diets throughout pregnancy. maternal body weight and composition were regularly assessed and advanced noninvasive imaging was performed at midgestation (gestation

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Author

Salati, Jennifer A.; Roberts, Victoria H. J.; Schabel, Matthias C.; Lo, Jamie O.; Kroenke, Christopher D.; Lewandowski, Katherine S.; Lindner, Jonathan R.; Grove, Kevin L.; Frias, Antonio E.

Publisher

Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1476-5497)

Published

2018

Language

EN

Field

Medicine (Health Sciences)