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Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial by D C Kieslinger; C G Vergouw; L Ramos; B Arends; M H J M Curfs; E Slappendel; E H Kostelijk; M H E C Pieters; D Consten; M O Verhoeven; D E Besselink; F Broekmans; B J Cohlen; J M J Smeenk; S Mastenbroek; C H de Koning; Y M van Kasteren; E Moll; J van Disseldorp; E A Brinkhuis; E A M Kuijper; W M van Baal; H G I van Weering; P J Q van der Linden; M H Gerards; P M Bossuyt; M van Wely; C B Lambalk is a Social Sciences article available to read on EtoBox.

What is Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial about?

Background Time-lapse monitoring is increasingly used in fertility laboratories to culture and select embryos for transfer. This method is offered to couples with the promise of improving pregnancy chances, even though there is currently insufficient evidence for superior clinical results. We aimed to evaluate whether a potential improvement by time-lapse monitoring is caused by the time-lapse-based embryo selection method itself or the uninterrupted culture environment that is part of the system. Methods In this three-armed, multicentre, double-blind, randomised controlled trial, couples undergoing in-vitro fertilisation or intracytoplasmic sperm injection were recruited from 15 fertility clinics in the Netherlands and randomly assigned using a web-based, computerised randomisation service to one of three groups. Couples and physicians were masked to treatment group, but embryologists and laboratory technicians could not be. The time-lapse early embryo viability assessment (EEVA; TLE) group received embryo selection based on the EEVA time-lapse selection method and uninterrupted culture. The time-lapse routine (TLR) group received routine embryo selection and uninterrupted culture

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Author

D C Kieslinger; C G Vergouw; L Ramos; B Arends; M H J M Curfs; E Slappendel; E H Kostelijk; M H E C Pieters; D Consten; M O Verhoeven; D E Besselink; F Broekmans; B J Cohlen; J M J Smeenk; S Mastenbroek; C H de Koning; Y M van Kasteren; E Moll; J van Disseldorp; E A Brinkhuis; E A M Kuijper; W M van Baal; H G I van Weering; P J Q van der Linden; M H Gerards; P M Bossuyt; M van Wely; C B Lambalk

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Social Sciences