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Environmental Pollution, 362 (2024) 124922. doi:10.1016/j.envpol.2024.124922ABSTRACTKeywords:Bisphenol A (BPA), a prevalent plastic monomer and endocrine disruptor, negatively impacts metabolic funcBisphenol Ations. This study examines the chronic effects of eco-relevant BPA concentrations on hepatotoxicity, focusing on Hepatotoxicityredox balance, inflammatory response, cellular energy sensors, and metabolic homeostasis in male Swiss albino Oxidative stressmice. Chronic BPA exposure resulted in reactive oxygen species (ROS) accumulation, altered hepatic antioxidant Inflammatory signallingdefense, lipid peroxidation, and NOX4 expression, leading to reduced cell viability. Additionally, BPA exposure Energy dysregulationsignificantly upregulated hepatic pro-inflammatory cytokine genes (Tnf-α, Il-1β, Il-6), NOS2, and arginase II, Liver metabolismcorrelating with increased TLR4 expression, NF-κB phosphorylation, and a dose-dependent decrease in IκBα levels. BPA-induced NF-κB nuclear localization and inflammasome activation (NLRP3, cleaved caspase-1, IL-1β) established an inflammatory milieu. Perturbations in hepatic AMPKα phosphorylation, SIRT1, and PGC-1α, along with elevated p38 MAP

Author

Sriparna Das

Publisher

x

Published

2024

Language

EN