Can I read Bromocriptine on EtoBox?

Bromocriptine by Herbert Roehrich; Charles A. Dackis; Mark S. Gold is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Bromocriptine about?

Shelesnyak determined that ergot alkaloids suppress prolactin secreti0n.l Further research to find an ergot alkaloid suitable for clinical use led to subsequent synthesis of bromocriptine. The animal pharmacology of bromocriptine has been thoroughly reviewed and will be briefly summarized here.' Animal studies demonstrate a direct action on pituitary l a c t ~t r o p h s . ~~ This action involves binding to dopamine receptors with a subsequent decrease in prolactin release.6 Bromocriptine does not affect GH secretion in animal studies and has not been studied for effect on ACTH s e c r e t i ~n . ~, ~ Bromocriptine inhibits MSH secretion, and its effects on TSH have not been studied."O Neurochemical evidence indicates that bromocriptine acts as a direct agonist on dopamine receptors." In rat models, this agonist action results in elevated brain dopamine content and a diminished rate of dopamine depletion after synthesis inhibition.''-15 Receptor binding studies suggest that bromocriptine also has dopamine antagonist properties and that the agonist and antagonist properties are mediated by at least two distinct dopamine receptor type^.^,'^,^^ Further, bromocriptine has been found to

Who reads Bromocriptine?

Author

Herbert Roehrich; Charles A. Dackis; Mark S. Gold

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0198-6325)

Published

1987

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)