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Can I read Combinatorial Intracellular Delivery Screening of Anticancer Drugs on EtoBox?
Combinatorial Intracellular Delivery Screening of Anticancer Drugs by Sola-Barrado, Belen; M. Leite, Diana; Scarpa, Edoardo; Duro-Castano, Aroa; Battaglia, Giuseppe is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Combinatorial Intracellular Delivery Screening of Anticancer Drugs about?
Conventional drug solubilization strategies limit the understanding of the full potential of poorly water-soluble drugs during drug screening. Here, we propose a screening approach in which poorly water-soluble drugs are entrapped in poly(2-(methacryloyloxyethyl phosphorylcholine)-poly(2-(diisopropylaminoethyl methacryate) (PMPC-PDPA) polymersomes (POs) to enhance drug solubility and facilitate intracellular delivery. By using a human pediatric glioma cell model, we demonstrated that PMPC-PDPA POs mediated intracellular delivery of cytotoxic and epigenetic drugs by receptor-mediated endocytosis. Additionally, when delivered in combination, drug-loaded PMPC-PDPA POs triggered both an enhanced drug efficacy and synergy compared to that of a conventional combinatorial screening. Hence, our comprehensive synergy analysis illustrates that our screening methodology, in which PMPC-PDPA POs are used for intracellular codelivery of drugs, allows us to identify potent synergistic profiles of anticancer drugs.
Who reads Combinatorial Intracellular Delivery Screening of Anticancer Drugs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sola-Barrado, Belen; M. Leite, Diana; Scarpa, Edoardo; Duro-Castano, Aroa; Battaglia, Giuseppe
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 1543-8384)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)