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The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract by Silvana Petrović; Silva Dobrić; Neda Mimica-Dukić; Nataša Simin; Jelena Kukić; Marjan Niketić is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH~2~Cl~2~ extract of western Balkan endemic __Hieracium gymnocephalum__ Griseb. ex Pant. (Compositae). The carrageenan‐induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration‐dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the antiinflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the __H. gymnocephalum__ extract, investigated using DPPH radical as

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Author

Silvana Petrović; Silva Dobrić; Neda Mimica-Dukić; Nataša Simin; Jelena Kukić; Marjan Niketić

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)