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The Mechanism of Genetic Resistance to Marek's Disease in Chickens by P. C. Powell; Brenda M. Mustill; M. Rennie; Lucy F. Lee is a Medicine article available to read on EtoBox.
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## Abstract Genetic resistance to Marek's disease in RPL line‐6 chickens is expressed not only at the level of host immunological responses against virus and tumour antigens, but also at the level of target lymphoid cells for virus infection and transformation. The nature of the target cell involved was investigated. Spleen cells from susceptible line‐7 chickens adsorbed more Marek's disease virus and turkey herpesvirus __in vitro__ than line‐6 spleen cells. In the case of Marek's disease virus this was reflected in the replicative ability of the virus __in vivo__. Transplantation of thymus fragments from 1‐day‐old line‐7 chickens into thymectomized line‐6 chickens conferred a high degree of susceptibility on the latter, but the transplantation of spleen or bursa fragments had no significant effect. The reverse procedure, __i.e.__ grafting of line‐6 thymi into line‐7 chickens, did not diminish the susceptibility of the recipients. In each treatment group the observed titres of leukocyte‐associated viraemia correlated with the susceptibility of the group to Marek's disease. Histologically the grafted thymus fragments became depleted of lymphocytes immediately after transplantation.
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- Author
- P. C. Powell; Brenda M. Mustill; M. Rennie; Lucy F. Lee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1982
- Language
- EN
- Field
- Medicine (Health Sciences)