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The effect of charges on the corneal penetration of solid lipid nanoparticles loaded Econazole after topical administration in rabbits by Zhen Liang; Zhen Zhang; Ping Lu; Jingjing Yang; Lei Han; Susu Liu; Tianyang Zhou; Jingguo Li; Junjie Zhang is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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Fungal keratitis is an infectious disease caused by pathogenic fungi with a high blindness rate. Econazole (ECZ) is an imidazole antifungal drug with insoluble ability. Econazole-loaded solid lipid nanoparticles (E-SLNs) were prepared by microemulsion method, then modified with positive and negative charge. The mean diameter of cationic E-SLNs, nearly neutral E-SLNs and anionic E-SLNs were 18.73±0.14, 19.05±0.28, 18.54±0.10 nm respectively. The Zeta potential of these different charged SLNs formulations were 19.13±0.89, -2.20±0.10, -27.40±0.67 mV respectively. The Polydispersity Index (PDI) of these three kinds of nanoparticles were all about 0.2. The Transmission Electron Microscopy (TEM) and Differential Scanning Calorimetry (DSC) analysis showed that the nanoparticles were a homogeneous system. Compared with Econazole suspension (E-Susp), SLNs exhibited sustained release capability, stronger corneal penetration and enhanced inhibition of pathogenic fungi without irritation. The antifungal ability was further improved after cationic charge modification compared with E-SLNs. Studies on pharmacokinetics showed that the order of the AUC and t1/2 of different preparations was cationi

Who reads The effect of charges on the corneal penetration of solid lipid nanoparticles loaded Econazole after topical administration in rabbits?

Author

Zhen Liang; Zhen Zhang; Ping Lu; Jingjing Yang; Lei Han; Susu Liu; Tianyang Zhou; Jingguo Li; Junjie Zhang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)