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Supragingival Mycobiome and Inter-kingdom Interactions in Dental Caries by Baraniya, Divyashri; Chen, Tsute; Nahar, Anubhav; Alakwaa, Fadhl; Hill, Jennifer; Tellez, Marisol; Ismail, Amid; Puri, Sumant; Al-Hebshi, Nezar Noor is a Dentistry article available to read on EtoBox.

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## ABSTRACT **Background**: Recent studies have reveled the presence of a complex fungal community (mycobiome) in the oral cavity. However, the role of oral mycobiome in dental caries and its interaction with caries-associated bacteria is not yet clear. **Methods**: Whole-mouth supragingival plaque samples from 30 children (6–10 years old) with no caries, early caries, or advanced caries were sequenced for internal transcribed spacer 2 (ITS-2). The mycobiome profiles were correlated with previously published bacteriome counterparts. Interaction among selected fungal and bacterial species was assessed by co-culture or spent media experiments. **Results**: Fungal load was extremely low. __Candida, Malassezia, Cryptococcus,__ and __Trichoderma__ spp. were the most prevalent/abundant taxa. Advanced caries was associated with significantly higher fungal load and prevalence/abundance of __Candida albicans. Cryptococcus neoformans__ and __Candida sake__ were significantly over-abundant in early caries, while __Malassezia globosa__ was significantly enriched in caries-free subjects. __C. albicans__ correlated with __Streptococcus mutans__ and __Scardovia wiggsiae__ among other caries-assoc

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Author

Baraniya, Divyashri; Chen, Tsute; Nahar, Anubhav; Alakwaa, Fadhl; Hill, Jennifer; Tellez, Marisol; Ismail, Amid; Puri, Sumant; Al-Hebshi, Nezar Noor

Publisher

Co-Action Publishing; Informa UK (Taylor & Francis); Taylor & Francis; Järfälla: Co-Action Publishing, 2009-; Informa UK Limited (ISSN 2000-2297)

Published

2020

Language

EN

Field

Dentistry (Health Sciences)