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Acute Liver Dysfunction After Cardiac Arrest by Enrica Iesu; Federico Franchi; Federica Zama Cavicchi; Selene Pozzebon; Vito Fontana; Manuel Mendoza; Leda Nobile; Sabino Scolletta; Jean-Louis Vincent; Jacques Creteur; Fabio Silvio Taccone is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Acute Liver Dysfunction After Cardiac Arrest about?
Few data are available regarding hypoxic hepatitis (HH) and acute liver failure (ALF) in patients resuscitated from cardiac arrest (CA). The aim of this study was to describe the occurrence of these complications and their association with outcome. All adult patients admitted to the Department of Intensive Care following CA were considered for inclusion in this retrospective study. Exclusion criteria were early death ( 1.2 mg/dL and an international normalized ratio 1.5. HH was defined as an aminotransferase level >1000 IU/L. Neurological outcome was assessed at 3 months and an unfavourable neurological outcome was defined as a Cerebral Performance Categories (CPC) score of 3-5. A total of 374 patients (age 62 [52-74] years; 242 male) were included. ALF developed in 208 patients (56%) and HH in 27 (7%); 24 patients developed both conditions. Patients with HH had higher mortality (89% vs. 51% vs. 45%, respectively) and greater rates of unfavourable neurological outcome (93% vs. 60% vs. 59%, respectively) compared to those with ALF without HH (n = 184) and those without ALF or HH (n = 163; p = 0.03). Unwitnessed arrest, non-shockable initial rhythm, lack of bystander cardiopulmonary
Who reads Acute Liver Dysfunction After Cardiac Arrest?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Enrica Iesu; Federico Franchi; Federica Zama Cavicchi; Selene Pozzebon; Vito Fontana; Manuel Mendoza; Leda Nobile; Sabino Scolletta; Jean-Louis Vincent; Jacques Creteur; Fabio Silvio Taccone
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)