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Experimental Leishmania infection: Generation of T-helper 2 (Th2) cells in susceptible and resistant mice? by F. Sommer; M. Meixner; M. Röllinghoff; M. Lohoff is a Immunology and Microbiology article available to read on EtoBox.

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Treatment with chloroquine on 7w day after prknary infection, reduces significantly the cross protection to heterologous challenge. However, immune mice treated with chloroquine and challenged with homologous parasites still remain protected. Reinfection of immune mice (treated or not with chloroquine) with the mixtures of I? c. chabaudiand Ryoe/ii 17XLshowed very high parasftemias however after day 12 post challenge mice started to control the parasitemia in contrast to the controls. Conoiueion: These experiments confirm and extend earliest studies on the specificity of immunity induced in inbred mice to rodent malarias. They also demonstrate that cross protection against heterotogous challenge is lost when primary parasitemia is stopped at 7 day after infection using chloroquine.

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Author

F. Sommer; M. Meixner; M. Röllinghoff; M. Lohoff

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)