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Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke by Zhang, Huiting; Pan, Qunwen; Xie, Zi; Chen, Yanyu; Wang, Jinju; Bihl, Ji; Zhong, Wangtao; Chen, Yanfang; Zhao, Bin; Ma, Xiaotang is a Medicine article available to read on EtoBox.

What is Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke about?

The role of miR-503 in brain endothelium and ischemic stroke (IS) remains unclear. We aimed to study the relationship between plasma miR-503 and the onset time, severity, subtypes, and von Willebrand Factor (vWF) level in IS patients and to investigate the roles and underlying mechanisms of miR-503 in middle cerebral artery occlusion (MCAO) mice and cultured cerebral vascular endothelial cells (ECs). In MCAO mice, the effects of plasma from acute severe IS patients (ASS) with or without miR-503 antagomir on brain and ECs damage were determined. In cultured human ECs, the effects of miR-503 overexpression or knockdown on the monolayer permeability, apoptosis, ROS, and NO generation were investigated. For mechanism study, the PI3K/Akt/eNOS pathway, cleaved caspase-3, and bcl-2 were analyzed. Results showed that plasma miR-503 was significantly increased in IS patients, especially in acute period and severe cases and subtypes of LAA and TACI, and was positively correlated with vWF. Logistic analysis indicated that miR-503 was an independent risk factor for IS, with the area under curve of 0.796 in ROC analysis. In MCAO mice, ASS pretreatment aggravated neurological injury, BBB damage,

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Author

Zhang, Huiting; Pan, Qunwen; Xie, Zi; Chen, Yanyu; Wang, Jinju; Bihl, Ji; Zhong, Wangtao; Chen, Yanfang; Zhao, Bin; Ma, Xiaotang

Publisher

Springer-Verlag; Springer New York LLC; Springer Science and Business Media LLC (ISSN 1868-4483)

Published

2020

Language

EN

ISBN

9781297502002

Field

Medicine (Health Sciences)