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Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study by David Saadoun; Amine Ghembaza; Sebastien Riviere; Arsene Mekinian; Jonathan Boutemy; Gaelle Leroux; Fanny Domont; Helene Maillard; Mathieu Vautier; Patrice Cacoub is a Medicine article available to read on EtoBox.

What is Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study about?

## Objective: To report the efficacy of rituximab plus belimumab in patients with refractory cryoglobulinemia vasculitis (cv). ## Methods: Belimumab was administered intravenously at a dose of 10 mg/kg on days 0, 14, 28 and then every month in association with rituximab in 4 patients with refractory cv. demographic, clinical and laboratory characteristics, treatment modalities and outcomes were recorded. ## Results: All patients had type ii igm kappa cryoglobulinemia, which was associated with primary sjögren syndrome (n = 1), hepatitis c virus infection (n = 1), and essential (n = 2). main manifestations of cv included purpura (n = 4), arthralgia and peripheral neuropathy (n = 3), and glomerulonephritis and skin ulcers (n = 1). in all cases, cv was refractory and/or relapse following rituximab. intravenous belimumab infusion along with rituximab resulted in rapid clinical response in the four patients. osteitis and recurrent urinary tract infections occurred in two patients. ## Conclusion: Belimumab along with rituximab showed promising results in refractory patients with cv.

Who reads Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study?

Author

David Saadoun; Amine Ghembaza; Sebastien Riviere; Arsene Mekinian; Jonathan Boutemy; Gaelle Leroux; Fanny Domont; Helene Maillard; Mathieu Vautier; Patrice Cacoub

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0896-8411)

Published

2020

Language

EN

Field

Medicine (Health Sciences)