Can I read MDM2-p53 Interaction Disruption by NSC 333003 on EtoBox?

MDM2-p53 Interaction Disruption by NSC 333003 by morastocco is a document available to read on EtoBox.

What is MDM2-p53 Interaction Disruption by NSC 333003 about?

NSC 333003 has been identified as a potent inhibitor of the MDM2-p53 protein-protein interaction through high-throughput in silico docking and subsequent experimental validation. The compound, synthesized from benzothiazole hydrazine and pyridyl phenyl ketone, shows promise for lead optimization due to its favorable chemical properties. Its biological activity was confirmed with an IC50 of approximately 20-25 μM, indicating potential for further development in cancer therapy targeting wild-type p53 tumors.

Author

morastocco

Language

EN