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Genome Recoding Strategies to Improve Cellular Properties: Mechanisms and Advances by Tanya Singh; Sudesh Kumar Yadav; Alexander Vainstein; Vinay Kumar is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Genome Recoding Strategies to Improve Cellular Properties: Mechanisms and Advances about?

The genetic code, once believed to be universal and immutable, is now known to contain many variations and is not quite universal. The basis for genome recoding strategy is genetic code variation that can be harnessed to improve cellular properties. Thus, genome recoding is a promising strategy for the enhancement of genome flexibility, allowing for novel functions that are not commonly documented in the organism in its natural environment. Here, the basic concept of genetic code and associated mechanisms for the generation of genetic codon variants, including biased codon usage, codon reassignment, and ambiguous decoding, are extensively discussed. Knowledge of the concept of natural genetic code expansion is also detailed. The generation of recoded organisms and associated mechanisms with basic targeting components, including aminoacyl-tRNA synthetase-tRNA pairs, elongation factor EF-Tu and ribosomes, are highlighted for a comprehensive understanding of this concept. The research associated with the generation of diverse recoded organisms is also discussed. The success of genome recoding in diverse multicellular organisms offers a platform for expanding protein chemistry at the b

Who reads Genome Recoding Strategies to Improve Cellular Properties: Mechanisms and Advances?

Author

Tanya Singh; Sudesh Kumar Yadav; Alexander Vainstein; Vinay Kumar

Publisher

Springer-Verlag; Springer Science and Business Media LLC (ISSN 2096-6326)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)