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Curcumin Improves Hippocampal Function in Healthy Older Adults: a Three Month Randomised Controlled Trial by Andrew Scholey; Katherine Cox; Andrew Pipingas; David White is a Medicine article available to read on EtoBox.

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Abstract The flavonoid curcumin is believed to be responsible for the purported health benefits of turmeric. Like other flavonoids, curcumin affects several systemic and central processes involved in neurocognitive aging. We have previously shown that one month administration of a highly bioavailable curcumin extract (LongvidaTM) improved working memory and reduced fatigue and workload stress in an older, cognitively intact cohort(1). This study focused on the effects of the same extract, focusing on memory tasks subserved by the hippocampus, one of two areas of the adult brain believed to be capable of adult neurogenesis. Eighty healthy older participants (aged 50–80 years, mean = 68.1, ± SD 6.34) took part in this double-blind, placebo-controlled, parallel-groups trial. Volunteers were randomised to receive administration of 400 mg daily LongvidaTM (containing 80 mg curcumin) or a matching placebo. Assessment took place at baseline and 4 and 12 weeks thereafter. Outcomes included two tasks evaluating memory processes relevant to hippocampal function. These were i) a human analogue of the widely used rodent Morris Water Maze - the virtual Morris Water Maze (vMWM) and ii) a Mnemoni

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Author

Andrew Scholey; Katherine Cox; Andrew Pipingas; David White

Publisher

Cambridge University Press; Cambridge University Press (CUP); CABI Publishing (ISSN 0029-6651)

Published

2020

Language

EN

Field

Medicine (Health Sciences)