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Fluorescence-based Sensing of P-nitrophenol and P-nitrophenyl Substituent Organophosphates by Sheetal Paliwal; Melinda Wales; Theresa Good; Janet Grimsley; James Wild; Aleksandr Simonian is a Chemistry article available to read on EtoBox.

What is Fluorescence-based Sensing of P-nitrophenol and P-nitrophenyl Substituent Organophosphates about?

A novel detection method for organophosphate neurotoxins has been described, based on the fluorescence quenching of a Coumarin derivative. These dyes are similar in structure to some organophosphates (OPs), and they fluoresce in the blue-green region of the spectra. This methodology has been utilized for the detection of organophosphates whose hydrolysis product is p-nitrophenol by using an enzyme, organophosphorus hydrolase (OPH). Coumarin1 in the presence of p-nitrophenol results in a quenching of fluorescence, providing a direct measure of the concentration of p-nitrophenol present in the sample. The decrease in fluorescence intensity is proportional to the paraoxon concentration in the range of 7.0 × 10 -7 -1.7 × 10 -4 M. The specificity of this sensing application for p-nitrophenyl substituent OPs has also been demonstrated. OPs are a class of synthetic organic pesticides which generally have a short residual life and can cause numerous acute and chronic health effects. They have been an integral part of the agricultural industry for the past several decades due to their target specificities and selectable toxicities. The toxic nature of these compounds can be attributed to th

Who reads Fluorescence-based Sensing of P-nitrophenol and P-nitrophenyl Substituent Organophosphates?

Author

Sheetal Paliwal; Melinda Wales; Theresa Good; Janet Grimsley; James Wild; Aleksandr Simonian

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)