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Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases by Meenu Mehta; Deeksha; Neha Sharma; Manish Vyas; Navneet Khurana; Pawan Kumar Maurya; Harjeet Singh; Terezinha Pinto Andreoli de Jesus; Harish Dureja; Dinesh Kumar Chellappan; Gaurav Gupta; Ridhima Wadhwa; Trudi Collet; Philip M Hansbro; Kamal Dua; Saurabh Satija is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases about?
Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.
Who reads Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Meenu Mehta; Deeksha; Neha Sharma; Manish Vyas; Navneet Khurana; Pawan Kumar Maurya; Harjeet Singh; Terezinha Pinto Andreoli de Jesus; Harish Dureja; Dinesh Kumar Chellappan; Gaurav Gupta; Ridhima Wadhwa; Trudi Collet; Philip M Hansbro; Kamal Dua; Saurabh Satija
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-2797)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)